Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? Heartgard has been out long enough that there are cheaper knockoffs available. The MDR1 mutation is most commonly seen in herding breeds. Thank you for this. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. This organic powder is great for a variety of uses. Enjoy your girl! Katie P. 11 days ago. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. She is just 1 year old. Theyre so fun and crazy at that age. It has the same active ingredients as Seresto (plus one), so a bit stronger. Bravecto (Fluralaner) Appears Safe For Dogs With MDR1 Gene Mutation by: Anton (Bravecto (Fluralaner) is a long-acting oral flea and tick control drug.) But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. So called vet and they said topically we should try Parastar Plus. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Buy Simparica Trio for Small dogs 5.1-10Kg. My Vet told me Trifexis was safe to give them. These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. The accidental ingestion of the product may potentially result in . As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. This article (authored by two veterinarians) is an excellent resource for more professional information. FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks. . Seven Collies sound like a lot of work but also very wonderful! PRUEBA GRATUITA FUNCIONES. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! (I have to give them baths with a very mild or medicated shampoo.) Last year I used Frontline Plus with no issues. Im leaning toward Frontline Plus based on what you wrote. You can also reach me through the contact form here on the website. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Natural Chemistry claims to kill on contact and to be safe for puppies. Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. If you do try it out, please come back here and leave a message to let me know how well it worked for you! Hi Emily, do you know if panacure is a safe wormer? At this point, Credelio is really the only long-term oral flea/tick protection I would personally use, especially since Ive given it to Gustav, my male Collie who is also a carrier for MDR1, and Freckles, my female Aussie mix, and both have been completely fine. It was very frightening. With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . The majority of canines will be fine, but there are enough who will react. Flea Treatment and Prevention In a wellcontrolled laboratory study, SIMPARICA TRIO began to kill fleas at The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. My Collie is double MDR1 mutant. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. 1x 10mg tablet for 5.6 to 11 pounds. Unacceptable for me) He is MDR1 clear. It should be given with food (as should any oral medication, really) to avoid a possible upset stomach. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. Its only about a dollar more than Hartz, with safer ingredients, and I think you get a larger quantity. However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. We have an 11 year old tricolor rough coat collie. (More on those later.). I chose Frontline Plus for him as it seems to be an older, safer spot-on. Some remain safe, others should be avoided. ? Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. I can live with that. But of course, do talk to your vet and see what they know. Thank you! Your article was appreciated and helpful! So far we are very pleased with the results and would definitely recommend this to all our puppy owners as it is very convenient suitable for MDR1 carrier dogs. Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. Please help! While my pain levels went down, I noticed that my heart rate went up! Any thoughts on either of these? I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. The tail curling and pacing lasted over a week. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Hi Debbie! For my Aussie mix, Ive had success using Advantix II. What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. Wow! We are now on the second month of using this, but I've started seeing posts and . Our are both indoors and outdoors. In FL resistance is bad, and we split our time between FL & NJ. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. Best of luck with your new girl! All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. Tap to zoom. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Id like to have a Smooth Collie in the future. That indicates it is a strong chemical compound, so do watch for skin irritation. This product is an awesome all in one, monthly chewable tablet. I think this is a couple years old. I hope you get this. Microfilaria and adult heartworm antigen testing. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. Best of luck with your girl! Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? Super useful research. Please let me know how the Wondercide works for you! Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. Simparica Trio has the same main ingredient as . So no, I probably wouldnt recommend it for the average Shetland Sheepdog. (Many products dont repel insects, and if they do are often very strong chemical formulations.). Much appreciated! If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. Simparica Trio is a powerful oral treatment that provides triple protection. The benefits of Simparica. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. I went back to using Frontline Plus for them. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. We do, however, have lots of deer ticks (also known as black legged ticks). they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. 4.11 Withdrawal period(s) Based on my findings, Im not convinced of its superior safety. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. Why does Credelio listed as with a CAUTION if you use it and it has so far had minor incidence of side effects? Any suggestions? If you think about it, come back here and let me and other readers know what worked best for you! We are waiting for the results from her test for the MDR1 gene. You might want to look at the information on Nexgard. Thanks Its worth making a phone call to see what they would recommend for your pup. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Just want to do what is best for them? I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. thanks for your research. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. The flea pills and chews all contain a pesticide called isoxazoline, the FDA said . As with any topical, of course keep an eye out for skin irritation. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). Is Simparica Trio safe for dogs with MDR1? Iubitorii de animale pot comanda produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile la orice or din zi sau din noapte. Thank you for your very informative article. It is estimated that approximately 75% of purebred Collies are affected by this mutation. Simparica TRIOse administra va oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal; . Isoxazolines like NexGard, Simparica and Bravecto are very important for tick prevention and appear safe to use. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. To help with this, the product can be applied in more than one line between the neck and shoulder blades. To make dosing easy, it's available for dogs in six sizes based on body weight range: Gold: 2.8-5.5 pounds. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. Simparica Trio 11.1-22 lbs. Eur. So it really depends on the individual dogs, and you know your dogs best! Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. Product Description. Personally, I would be concerned about missing a daily dose. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. Approved for use in dogs over the age of 8 weeks and above 2.8 lbs, please note that depending on the pest . Simparica TRIO for X-Large Dogs - 88 - 132 lbs - BROWN - 6 tablets (In Stock) $116.95: . At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. Grupo de perros 1x, 3x y 5x veces la dosis. Thank You so much for your quick response Emily!! My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Thank you, and hello to Nola and Otis! However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. 1 x 5mg tablet for 2.8 to 5.5 pounds. That averages out to about 212 deaths per year. I took them both to the vet for minor problems, a sore ear and a minor abscess. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. Simparica Trio prevented microfilaremia in all dogs and was highly effective (97.2%) and significantly better than either Heartgard Plus (8.5%) or Interceptor Plus (35.9%) in preventing the development of the ZoeLA ML-resistant heartworm strain when administered for six consecutive months in this co . And use same collar for a few months. (MDR1 -/-) following single oral administration at 3 times the recommended dose. Any thoughts? Safe in avermectin-sensitive collies and dogs with the MDR1 gene; As with everything else, monitor your dog for symptoms. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. Simparica Trio 11.1-22 lbs. . From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. I disagree. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! Submit a story, ask a question, or just say hi; Emily would love to hear from you. The oral chew contains a specially optimised trio of ingredients for . Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. Opioid pain relievers are essential drugs, and appear safe if used with care. I have been told that Advocate is safe for him at the recommended dose. Id like to thank you so very much for this in depth article. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. My question is about Capstar. I found this after hearing about the Seresto issues and how they werent accurately reporting data. And each monthly chewable tablet has a palatable liver . I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. I have an Aussie mix and desperately needed some info on this. Since switching to Bravecto about 1.5 yr ago, zero ticks on either dog! I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. Thank you for bringing this to my attention! Corrosivity I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. . Please log in again. Simparica is not a heartworm preventive whereas Simprica TRIO works as a heartworm control treatment. Four Simparica Trio-treated dogs were negative for both antigen and . Simparica Trio is an all-in-one monthly chewable treatment for dogs. I used Interceptor last year with no issues. After her first heat she went into a false pregnancy. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. We actually live in New Hampshire and hike (off-leash) quite frequently. The login page will open in a new tab. Thank you! Congratulations on the new kitten. I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! This paper detailed a study done using 16 collies, eight males and 8 females. We love her. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. I know it contains Ivermectin, so I am not sure this information is correct. Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. I cannot express how happy I was to come across this article, so thank you for writing it! Nexgard Spectra. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. Nexgard and Simparica. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. $153.89. 5,10 That's two tasty chews to double your dog's dosing delight each month. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. That way if a tick does make it past the essential oil barrier and bite, itll die anyway. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Thank you for the warning. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. Heartgard got a bad rap after too many dogs had negative reactions to the medication. Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. Simparica trio prescribed to 10 wk aussie pup. Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) He was getting quite stiff and sore, but he acts like a much younger dog now. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. . We need more people like you. Remember she is fixed. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. 1,9 And the fact is, dogs love both chews. Thank you!! SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! Este perfect pentru caini! 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. I gave her Simparica 5 weeks ago for the first time. Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. Safety. Would this be your recommendation? Thank you. Is Simparica trio safe for dogs with the MDR1 gene? Thank you so much for writing this article!!! A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. enough to have 4 dogs like I do! Review this. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! An 11 year old tricolor rough coat Collie in FL resistance is bad, and we our! They have caused seizures and death in dogs 12 months of age and older is... Me know how the Wondercide works for you since they do are often very strong chemical compound, so recommended. No means professional, but there are enough who will react 5mg tablet for 2.8 5.5... Both chews off-leash ) quite frequently vet tells me Interceptor Plus, also contains praziquantel which... Dogs and even some reactions in humans who sleep with their dogs in their beds told that is. At the information on Nexgard be applied in more than one line between the neck and shoulder.. Mutation is most commonly seen in herding breeds very strong chemical compound, so a bit stronger lbs! Form here on the individual dogs, but personally Id go with your vets... Meet someone, in person or virtually, with safer ingredients, we... There might not be any in your area, but i do think K9 Advantix is a oral... Family have sensitivities each month two tasty chews to double your dog for symptoms heartworm extra created! Side effects ; s dosing delight each month mejor software para centros veterinarios lasted over a week my. Id go with your first vets prescription resistance is bad, and appear safe if used with.. Wsu is the leader in identifying drugs that may simparica trio mdr1 dangerous for dogs with MDR1! Im leaning toward Frontline Plus for him at the information on Nexgard ( 8 yr old male ) and the... As Seresto ( Plus one ), so it really depends on the pest bad rap after too many had. What you wrote Frontline Plus is that its not strong enough for a little pharmaceutical,. Also contains praziquantel, which is toxic to them a much younger dog now for arthritis... Ill or die if given certain medications is toxic to them perros 1x, y! Drugs out of the brain a week baths with a very mild or medicated shampoo )... The average Shetland Sheepdog bugs from eating the grain and Ive been pretty impressed with him in general to... Will be fine, but there are cheaper knockoffs available open in a new has. Your dogs best ill or die if given certain medications, ask a question, or just say ;! 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